A Literature Review on Multiple Courses of Antenatal Steroids to Prevent Neonatal Respiratory Distress Syndrome

Introduction: Repeat antenatal corticosteroids may reduce respiratory distress syndrome however there is conflicting evidence suggesting it may be unnecessary or harmful. This article reviews the literature to examine the role of multiple courses of antenatal steroids to prevent neonatal respiratory distress syndrome. Methods: Electronic databases were searched online. Results: Four randomised controlled trials were identified according to our inclusion criteria. Conclusions: There is evidence that courses of ACS improve pulmonary outcomes in the neonate, preventing RDS. There is evidence suggesting potential harm, and the lack of long term safety data, caution and careful patient selection is required when instituting this intervention.